Assay Detail
Binding
CHEMBL646565
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Binding affinity against alpha2-delta subunit of rat calcium channel
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Investigation into the preferred conformation of gabapentin for interaction with its binding site on the 2 subunit of a calcium channel
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.69 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL940 | GABAPENTIN | 4.0 | 1 | 6.85 |
| CHEMBL555731 | — | — | 1 | 6.84 |
| CHEMBL537990 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL940 | GABAPENTIN | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL555731 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL537990 | — | IC50 | = | 420.0 | nM | 6.38 |