Assay Detail
Binding
CHEMBL646568
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [125I]MAdCAM-Ig binding to human integrin alpha4-beta7 of RPMI-8866 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | RPMI-8866 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-aryl-prolyl-dipeptides as potent antagonists of VLA-4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.92 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69035 | — | — | 1 | 8.60 |
| CHEMBL307096 | — | — | 1 | 8.46 |
| CHEMBL305408 | — | — | 1 | 8.30 |
| CHEMBL69352 | — | — | 1 | 8.26 |
| CHEMBL308458 | — | — | 1 | 8.24 |
| CHEMBL70107 | — | — | 1 | 8.05 |
| CHEMBL71554 | — | — | 1 | 7.77 |
| CHEMBL367599 | — | — | 1 | 7.77 |
| CHEMBL422054 | — | — | 1 | 7.75 |
| CHEMBL68592 | — | — | 1 | 7.73 |
| CHEMBL69888 | — | — | 1 | 7.68 |
| CHEMBL71705 | — | — | 1 | 7.35 |
| CHEMBL71577 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69035 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL307096 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL305408 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL69352 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL308458 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL70107 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL71554 | — | IC50 | = | 17.1 | nM | 7.77 |
| CHEMBL367599 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL422054 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL68592 | — | IC50 | = | 18.8 | nM | 7.73 |
| CHEMBL69888 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL71705 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL71577 | — | IC50 | = | 110.0 | nM | 6.96 |