Assay Detail
Binding
CHEMBL646635
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Binding affinity towards Adenosine A3 receptor (W243 A mutant receptor)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.99 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464859 | NECA | — | 1 | 9.05 |
| CHEMBL139417 | — | — | 1 | 8.92 |
| CHEMBL133387 | — | — | 1 | 8.68 |
| CHEMBL138781 | — | — | 1 | 8.57 |
| CHEMBL66393 | — | — | 1 | 8.22 |
| CHEMBL337602 | — | — | 1 | 7.34 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 6.86 |
| CHEMBL342926 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464859 | NECA | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL139417 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL133387 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL138781 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL66393 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL337602 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL342926 | — | Ki | = | 490.0 | nM | 6.31 |