Assay Detail
Binding
CHEMBL646636
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Binding affinity towards Adenosine A3 receptor (W243 mutant receptor)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.25 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL342873 | — | — | 1 | 8.89 |
| CHEMBL307199 | — | — | 1 | 8.62 |
| CHEMBL284969 | — | — | 1 | 7.00 |
| CHEMBL344698 | — | — | 1 | 6.09 |
| CHEMBL111545 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL342873 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL307199 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL284969 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL344698 | — | Ki | = | 818.0 | nM | 6.09 |
| CHEMBL111545 | — | Ki | = | 2150.0 | nM | 5.67 |