Assay Detail
Binding
CHEMBL646740
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for binding affinity against calf intestinal Adenosine Deaminase (ADA)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Adenosine deaminase inhibitors. Synthesis and biological evaluation of putative metabolites of (+)-erythro-9-(2S-hydroxy-3R-nonyl)adenine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.38 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296435 | (+)-EHNA | — | 1 | 9.09 |
| CHEMBL127469 | — | — | 1 | 8.42 |
| CHEMBL123910 | — | — | 1 | 8.19 |
| CHEMBL332871 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296435 | (+)-EHNA | Ki | = | 0.82 | nM | 9.09 |
| CHEMBL127469 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL123910 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL332871 | — | Ki | = | 15.8 | nM | 7.80 |