Assay Detail
Binding
CHEMBL646943
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Binding affinity towards Angiotensin I converting enzyme of rat brain IgG immobilized enzyme.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Angiotensin-converting enzyme 2 (CHEMBL2311) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of phosphonamidate peptide inhibitors of enkephalinase and angiotensin-converting enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.67 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL577 | ENALAPRILAT ANHYDROUS | 4.0 | 1 | 9.30 |
| CHEMBL429227 | — | — | 1 | 5.55 |
| CHEMBL281394 | — | — | 1 | 5.47 |
| CHEMBL19352 | — | — | 1 | 5.19 |
| CHEMBL417094 | — | — | 1 | 5.18 |
| CHEMBL277431 | — | — | 1 | 4.96 |
| CHEMBL19443 | — | — | 1 | 4.07 |
| CHEMBL277394 | — | — | 1 | - |
| CHEMBL1744144 | — | — | 1 | - |
| CHEMBL20089 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL577 | ENALAPRILAT ANHYDROUS | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL429227 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL281394 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL19352 | — | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL417094 | — | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL277431 | — | Ki | = | 11100.0 | nM | 4.96 |
| CHEMBL19443 | — | Ki | = | 85000.0 | nM | 4.07 |
| CHEMBL277394 | — | Ki | = | 125000.0 | nM | - |
| CHEMBL1744144 | — | Ki | > | 150000.0 | nM | - |
| CHEMBL20089 | — | Ki | = | 120000.0 | nM | - |