Assay Detail
Binding
CHEMBL646972
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Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Adrenal cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Substituted piperidin-2-one biphenyltetrazoles as angiotensin II antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.56 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49207 | — | — | 1 | 7.70 |
| CHEMBL51084 | — | — | 1 | 7.40 |
| CHEMBL48459 | — | — | 1 | 7.05 |
| CHEMBL50906 | — | — | 1 | 6.92 |
| CHEMBL296731 | — | — | 1 | 6.92 |
| CHEMBL51622 | — | — | 1 | 6.75 |
| CHEMBL413098 | — | — | 1 | 6.70 |
| CHEMBL418269 | — | — | 1 | 6.68 |
| CHEMBL48602 | — | — | 1 | 6.60 |
| CHEMBL51001 | — | — | 1 | 6.50 |
| CHEMBL295369 | — | — | 1 | 6.48 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 6.38 |
| CHEMBL299151 | — | — | 1 | 6.33 |
| CHEMBL49192 | — | — | 1 | 6.27 |
| CHEMBL51078 | — | — | 1 | 6.17 |
| CHEMBL52046 | — | — | 1 | 5.51 |
| CHEMBL49262 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49207 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL51084 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL48459 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL50906 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL296731 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL51622 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL413098 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL418269 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL48602 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL51001 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL295369 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL191 | LOSARTAN | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL299151 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL49192 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL51078 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL52046 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL49262 | — | IC50 | = | 5800.0 | nM | 5.24 |