Assay Detail
Binding
CHEMBL646975
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Inhibition of [125l]-All binding to bovine adrenal cortex
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Adrenal cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Angiotensin II receptor antagonists: imidazoles and pyrroles bearing hydroxymethyl and carboxy substituents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.38 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | — | 1 | 7.66 |
| CHEMBL417366 | — | — | 1 | 7.24 |
| CHEMBL299809 | — | — | 1 | 7.19 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 6.92 |
| CHEMBL49170 | — | — | 1 | 6.89 |
| CHEMBL50092 | — | — | 1 | 6.82 |
| CHEMBL300186 | — | — | 1 | 6.50 |
| CHEMBL274447 | — | — | 1 | 6.31 |
| CHEMBL439743 | — | — | 1 | 6.08 |
| CHEMBL53631 | — | — | 1 | 5.68 |
| CHEMBL52601 | — | — | 1 | 5.57 |
| CHEMBL50592 | — | — | 1 | 5.35 |
| CHEMBL53322 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL417366 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL299809 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL191 | LOSARTAN | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL49170 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL50092 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL300186 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL274447 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL439743 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL53631 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL52601 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL50592 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL53322 | — | IC50 | = | 20000.0 | nM | 4.70 |