Assay Detail
Binding
CHEMBL646980
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Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortex
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Adrenal cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A new class of diacidic nonpeptide angiotensin II receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.64 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129447 | — | — | 1 | 7.44 |
| CHEMBL128920 | — | — | 1 | 7.32 |
| CHEMBL132109 | — | — | 1 | 7.27 |
| CHEMBL1016 | CANDESARTAN | 3.0 | 1 | 6.96 |
| CHEMBL340612 | — | — | 1 | 6.41 |
| CHEMBL334838 | — | — | 1 | 6.30 |
| CHEMBL436192 | — | — | 1 | 5.92 |
| CHEMBL128590 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129447 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL128920 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL132109 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1016 | CANDESARTAN | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL340612 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL334838 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL436192 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL128590 | — | IC50 | = | 3300.0 | nM | 5.48 |