Assay Detail
Functional
CHEMBL646981
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Adrenal cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
6-isoxazolinyl and isoxazolidinyl substituted quinazolinones as angiotensin II receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.17 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295529 | — | — | 1 | 7.66 |
| CHEMBL47177 | — | — | 1 | 7.57 |
| CHEMBL44526 | — | — | 1 | 7.52 |
| CHEMBL275875 | CL-329167 | — | 1 | 7.51 |
| CHEMBL47817 | — | — | 1 | 7.50 |
| CHEMBL45864 | — | — | 1 | 7.46 |
| CHEMBL295695 | — | — | 1 | 7.42 |
| CHEMBL44798 | — | — | 1 | 7.41 |
| CHEMBL45805 | — | — | 1 | 7.34 |
| CHEMBL47873 | — | — | 1 | 7.33 |
| CHEMBL295532 | — | — | 1 | 7.26 |
| CHEMBL296519 | — | — | 1 | 7.25 |
| CHEMBL296518 | — | — | 1 | 7.24 |
| CHEMBL44749 | — | — | 1 | 7.24 |
| CHEMBL295514 | — | — | 1 | 7.21 |
| CHEMBL44690 | — | — | 1 | 7.19 |
| CHEMBL46361 | — | — | 1 | 7.19 |
| CHEMBL44605 | — | — | 1 | 7.16 |
| CHEMBL294992 | — | — | 1 | 7.16 |
| CHEMBL296719 | — | — | 1 | 7.16 |
| CHEMBL263471 | — | — | 1 | 7.16 |
| CHEMBL45766 | — | — | 1 | 7.10 |
| CHEMBL47583 | — | — | 1 | 7.08 |
| CHEMBL295905 | — | — | 1 | 6.85 |
| CHEMBL297583 | — | — | 1 | 6.75 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 6.48 |
| CHEMBL295279 | — | — | 1 | 6.39 |
| CHEMBL47872 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295529 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL47177 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL44526 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL275875 | CL-329167 | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL47817 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL45864 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL295695 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL44798 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL45805 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL47873 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL295532 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL296519 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL296518 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL44749 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL295514 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL44690 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL46361 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL44605 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL294992 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL296719 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL263471 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL45766 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL47583 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL295905 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL297583 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL191 | LOSARTAN | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL295279 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL47872 | — | IC50 | = | 500.0 | nM | 6.30 |