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Assay Detail

CHEMBL646982

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Adrenal cortex
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Type-1 angiotensin II receptor (CHEMBL3374)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazolecarboxylic acids.
Kubo K, Kohara Y, Imamiya E, Sugiura Y, Inada Y, Furukawa Y, Nishikawa K, Naka T.
J Med Chem (1993) 36 : 2182 -2195
PubMed 8340921 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 43 6.48 7.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL309084 1 7.50
CHEMBL70242 1 7.41
CHEMBL69154 1 7.34
CHEMBL71410 1 7.21
CHEMBL308884 1 7.18
CHEMBL433099 1 7.09
CHEMBL302520 1 7.08
CHEMBL1016 CANDESARTAN 3.0 1 6.96
CHEMBL304772 1 6.92
CHEMBL71384 1 6.92
CHEMBL308651 1 6.82
CHEMBL995 LOSARTAN POTASSIUM 4.0 1 6.82
CHEMBL305190 1 6.77
CHEMBL70074 1 6.77
CHEMBL68597 1 6.77
CHEMBL69522 1 6.72
CHEMBL303955 1 6.72
CHEMBL71954 1 6.72
CHEMBL69144 1 6.60
CHEMBL69236 1 6.52
CHEMBL68494 1 6.36
CHEMBL420551 1 6.36
CHEMBL71038 1 6.31
CHEMBL48242 1 6.26
CHEMBL68516 1 6.25
CHEMBL303170 1 6.24
CHEMBL302973 1 6.24
CHEMBL70947 1 6.21
CHEMBL302811 1 6.19
CHEMBL302127 1 6.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL309084 IC50 = 32.0 nM 7.50
CHEMBL70242 IC50 = 39.0 nM 7.41
CHEMBL69154 IC50 = 46.0 nM 7.34
CHEMBL71410 IC50 = 62.0 nM 7.21
CHEMBL308884 IC50 = 66.0 nM 7.18
CHEMBL433099 IC50 = 82.0 nM 7.09
CHEMBL302520 IC50 = 84.0 nM 7.08
CHEMBL1016 CANDESARTAN IC50 = 110.0 nM 6.96
CHEMBL304772 IC50 = 120.0 nM 6.92
CHEMBL71384 IC50 = 120.0 nM 6.92
CHEMBL995 LOSARTAN POTASSIUM IC50 = 150.0 nM 6.82
CHEMBL308651 IC50 = 150.0 nM 6.82
CHEMBL305190 IC50 = 170.0 nM 6.77
CHEMBL70074 IC50 = 170.0 nM 6.77
CHEMBL68597 IC50 = 170.0 nM 6.77
CHEMBL69522 IC50 = 190.0 nM 6.72
CHEMBL71954 IC50 = 190.0 nM 6.72
CHEMBL303955 IC50 = 190.0 nM 6.72
CHEMBL69144 IC50 = 250.0 nM 6.60
CHEMBL69236 IC50 = 300.0 nM 6.52
CHEMBL420551 IC50 = 440.0 nM 6.36
CHEMBL68494 IC50 = 440.0 nM 6.36
CHEMBL71038 IC50 = 490.0 nM 6.31
CHEMBL48242 IC50 = 550.0 nM 6.26
CHEMBL68516 IC50 = 560.0 nM 6.25
CHEMBL303170 IC50 = 580.0 nM 6.24
CHEMBL302973 IC50 = 580.0 nM 6.24
CHEMBL70947 IC50 = 620.0 nM 6.21
CHEMBL302811 IC50 = 650.0 nM 6.19
CHEMBL302127 IC50 = 800.0 nM 6.10
CHEMBL71550 IC50 = 850.0 nM 6.07
CHEMBL303264 IC50 = 930.0 nM 6.03
CHEMBL302815 IC50 = 1000.0 nM 6.00
CHEMBL67636 IC50 = 3200.0 nM 5.50
CHEMBL69124 IC50 = 3900.0 nM 5.41
CHEMBL304360 IC50 = 13000.0 nM 4.89
CHEMBL308911 IC50 = 45000.0 nM 4.35
CHEMBL69221 IC50 > 1000.0 nM -
CHEMBL68732 IC50 > 1000.0 nM -
CHEMBL68622 IC50 > 1000.0 nM -
CHEMBL307128 IC50 > 1000.0 nM -
CHEMBL71545 IC50 > 1000.0 nM -
CHEMBL68370 IC50 > 100.0 nM -