Assay Detail
Binding
CHEMBL647000
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Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and structure-activity relationships of a new series of alpha-adrenergic agonists: spiro[(1,3-diazacyclopent-1-ene)-5,2'-(1',2',3',4'- tetrahydronaphthalene)].
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.89 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL133231 | — | — | 1 | 7.70 |
| CHEMBL98471 | — | — | 1 | 7.30 |
| CHEMBL338683 | — | — | 1 | 7.02 |
| CHEMBL133579 | — | — | 1 | 7.00 |
| CHEMBL131417 | — | — | 1 | 7.00 |
| CHEMBL131220 | — | — | 1 | 6.82 |
| CHEMBL336332 | — | — | 1 | 6.80 |
| CHEMBL101340 | — | — | 1 | 6.75 |
| CHEMBL130853 | — | — | 1 | 6.56 |
| CHEMBL336970 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL133231 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL98471 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL338683 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL133579 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL131417 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL131220 | — | Ki | = | 152.0 | nM | 6.82 |
| CHEMBL336332 | — | Ki | = | 159.0 | nM | 6.80 |
| CHEMBL101340 | — | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL130853 | — | Ki | = | 275.0 | nM | 6.56 |
| CHEMBL336970 | — | Ki | = | 1200.0 | nM | 5.92 |