Assay Detail
Binding
CHEMBL647005
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The compound's binding affinity against Alpha-2B adrenergic receptor from rat kidney homogenate in the presence of phentolamine
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Kidney |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective alpha 1-adrenoceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Log Ki | 3 | - | - |
| Ki | 1 | 7.10 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90746 | — | — | 1 | 7.10 |
| CHEMBL88160 | — | — | 1 | - |
| CHEMBL420620 | — | — | 1 | - |
| CHEMBL89030 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90746 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL88160 | — | Log Ki | = | 8.6 | uM | - |
| CHEMBL420620 | — | Log Ki | = | 6.5 | uM | - |
| CHEMBL89030 | — | Log Ki | = | 6.5 | uM | - |