Assay Detail
Binding
CHEMBL647046
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Inhibition of binding of [125I]HEAT to cloned human alpha-1A adrenergic receptor.
29
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Phenylacetamides as selective alpha-1A adrenergic receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 7.79 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44294 | — | — | 1 | 9.00 |
| CHEMBL415887 | — | — | 1 | 8.96 |
| CHEMBL298058 | — | — | 1 | 8.89 |
| CHEMBL41994 | — | — | 3 | 8.70 |
| CHEMBL42514 | — | — | 1 | 8.47 |
| CHEMBL41844 | — | — | 1 | 8.44 |
| CHEMBL41677 | — | — | 1 | 8.29 |
| CHEMBL289339 | — | — | 1 | 8.19 |
| CHEMBL44124 | — | — | 1 | 8.14 |
| CHEMBL297667 | — | — | 1 | 8.13 |
| CHEMBL42220 | — | — | 1 | 8.12 |
| CHEMBL295304 | — | — | 1 | 8.06 |
| CHEMBL435576 | — | — | 1 | 7.92 |
| CHEMBL42763 | — | — | 1 | 7.66 |
| CHEMBL417350 | — | — | 1 | 7.62 |
| CHEMBL432302 | — | — | 1 | 7.60 |
| CHEMBL289916 | — | — | 1 | 7.57 |
| CHEMBL296965 | — | — | 1 | 7.55 |
| CHEMBL44496 | — | — | 1 | 7.33 |
| CHEMBL416073 | — | — | 1 | 7.30 |
| CHEMBL40303 | — | — | 1 | 7.21 |
| CHEMBL42361 | — | — | 1 | 7.14 |
| CHEMBL43799 | — | — | 1 | 7.13 |
| CHEMBL43749 | — | — | 1 | 7.12 |
| CHEMBL42156 | — | — | 1 | 6.62 |
| CHEMBL41959 | — | — | 1 | 6.42 |
| CHEMBL44288 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44294 | — | Ki | = | 0.99 | nM | 9.00 |
| CHEMBL415887 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL298058 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL41994 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL41994 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL42514 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL41844 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL41677 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL289339 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL44124 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL297667 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL42220 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL295304 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL435576 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL42763 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL417350 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL432302 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL289916 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL296965 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL44496 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL41994 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL416073 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL40303 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL42361 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL43799 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL43749 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL42156 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL41959 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL44288 | — | Ki | = | 570.0 | nM | 6.24 |