Assay Detail
Binding
CHEMBL647057
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In vitro binding affinity towards cloned human Alpha-1A adrenergic receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Cyclic imides as potent and selective alpha-1A adrenergic receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.99 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62045 | — | — | 1 | 9.32 |
| CHEMBL299914 | — | — | 1 | 8.77 |
| CHEMBL59590 | — | — | 1 | 8.70 |
| CHEMBL61643 | — | — | 1 | 8.24 |
| CHEMBL44124 | — | — | 1 | 8.14 |
| CHEMBL62249 | — | — | 1 | 8.01 |
| CHEMBL41677 | — | — | 1 | 7.77 |
| CHEMBL43799 | — | — | 1 | 7.13 |
| CHEMBL301416 | — | — | 1 | 7.11 |
| CHEMBL60452 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62045 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL299914 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL59590 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL61643 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL44124 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL62249 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL41677 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL43799 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL301416 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL60452 | — | Ki | = | 220.0 | nM | 6.66 |