Assay Detail
Binding
CHEMBL647058
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Inhibition of [3H]prazosin binding to cloned human Alpha-1A adrenergic receptor in CHO cells (chinese hamster ovary cells)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New potential uroselective NO-donor alpha1-antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 9.44 | 10.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338029 | — | — | 1 | 10.03 |
| CHEMBL338608 | — | — | 1 | 9.80 |
| CHEMBL278865 | UPIDOSIN | 2.0 | 1 | 9.47 |
| CHEMBL125989 | — | — | 1 | 9.14 |
| CHEMBL125365 | — | — | 1 | 8.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338029 | — | Ki | = | 0.094 | nM | 10.03 |
| CHEMBL338608 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL278865 | UPIDOSIN | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL125989 | — | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL125365 | — | Ki | = | 1.8 | nM | 8.74 |