Assay Detail

CHEMBL647063

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Inhibition of endothelial cell ploriferation determined in bovine aortic endothelial cell (BAEC)

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Bos taurus
Cell Type	Endothelial cell
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Fumagalone, a reversible inhibitor of type 2 methionine aminopeptidase and angiogenesis.

Zhou G, Tsai CW, Liu JO.
J Med Chem (2003) 46 : 3452 -3454
PubMed 12877582 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.70	6.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL32838	FUMAGILLIN	2.0	1	6.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL32838	FUMAGILLIN	IC50	=	200.0	nM	6.70