Assay Detail
Binding
CHEMBL647116
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Inhibitory potency against angiotensin converting enzyme by displacement of [3H]trandolaprilate binding in mouse lung
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme: rational design, bioavailability, and pharmacological responses in experimental hypertension.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.88 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273853 | — | — | 1 | 8.44 |
| CHEMBL275690 | — | — | 1 | 8.40 |
| CHEMBL11806 | — | — | 1 | 8.40 |
| CHEMBL11616 | — | — | 1 | 8.37 |
| CHEMBL11607 | — | — | 1 | 8.35 |
| CHEMBL276008 | — | — | 1 | 8.30 |
| CHEMBL6915 | — | — | 1 | 8.27 |
| CHEMBL273724 | — | — | 1 | 8.16 |
| CHEMBL11537 | — | — | 1 | 8.15 |
| CHEMBL11227 | — | — | 1 | 8.10 |
| CHEMBL11620 | — | — | 1 | 8.02 |
| CHEMBL11297 | — | — | 1 | 8.00 |
| CHEMBL273672 | — | — | 1 | 7.92 |
| CHEMBL11344 | — | — | 1 | 7.85 |
| CHEMBL273898 | — | — | 1 | 7.72 |
| CHEMBL2051773 | — | — | 1 | 7.70 |
| CHEMBL11495 | — | — | 1 | 7.60 |
| CHEMBL273748 | — | — | 1 | 7.50 |
| CHEMBL11236 | — | — | 1 | 7.37 |
| CHEMBL275980 | — | — | 1 | 7.00 |
| CHEMBL267766 | — | — | 1 | 6.96 |
| CHEMBL416522 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273853 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL275690 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL11806 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL11616 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL11607 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL276008 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL6915 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL273724 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL11537 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL11227 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL11620 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL11297 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL273672 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL11344 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL273898 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2051773 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL11495 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL273748 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL11236 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL275980 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL267766 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL416522 | — | IC50 | = | 210.0 | nM | 6.68 |