Assay Detail
Functional
CHEMBL647292
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO-C10 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.79 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL844 | BRIMONIDINE | 4.0 | 1 | 8.39 |
| CHEMBL308570 | — | — | 1 | 8.06 |
| CHEMBL432155 | — | — | 1 | 6.91 |
| CHEMBL75257 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL844 | BRIMONIDINE | EC50 | = | 4.1 | nM | 8.39 |
| CHEMBL308570 | — | EC50 | = | 8.7 | nM | 8.06 |
| CHEMBL432155 | — | EC50 | = | 124.0 | nM | 6.91 |
| CHEMBL75257 | — | EC50 | > | 5000.0 | nM | - |