Assay Detail
Binding
CHEMBL647510
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Binding affinity for angiotensin II AT-2 receptor
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Balanced angiotensin II receptor antagonists. III. The effects of substitution at the imidazole 5-position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 61 | 8.06 | 9.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71125 | — | — | 1 | 9.16 |
| CHEMBL74573 | — | — | 1 | 9.15 |
| CHEMBL71172 | — | — | 1 | 9.05 |
| CHEMBL71220 | — | — | 1 | 9.05 |
| CHEMBL70867 | — | — | 1 | 9.00 |
| CHEMBL311625 | — | — | 1 | 9.00 |
| CHEMBL72595 | — | — | 1 | 9.00 |
| CHEMBL307318 | — | — | 1 | 9.00 |
| CHEMBL302579 | — | — | 1 | 9.00 |
| CHEMBL70789 | — | — | 1 | 9.00 |
| CHEMBL70726 | — | — | 1 | 8.80 |
| CHEMBL306638 | — | — | 1 | 8.72 |
| CHEMBL308323 | — | — | 1 | 8.70 |
| CHEMBL70935 | — | — | 1 | 8.70 |
| CHEMBL73283 | — | — | 1 | 8.70 |
| CHEMBL306761 | — | — | 1 | 8.70 |
| CHEMBL71639 | — | — | 1 | 8.70 |
| CHEMBL70370 | — | — | 1 | 8.70 |
| CHEMBL305017 | — | — | 1 | 8.70 |
| CHEMBL302964 | — | — | 1 | 8.70 |
| CHEMBL69721 | — | — | 1 | 8.70 |
| CHEMBL70100 | — | — | 1 | 8.68 |
| CHEMBL72099 | — | — | 1 | 8.52 |
| CHEMBL303647 | — | — | 1 | 8.52 |
| CHEMBL74069 | — | — | 1 | 8.52 |
| CHEMBL70843 | — | — | 1 | 8.52 |
| CHEMBL309790 | — | — | 1 | 8.52 |
| CHEMBL74514 | — | — | 1 | 8.52 |
| CHEMBL307359 | — | — | 1 | 8.52 |
| CHEMBL307008 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71125 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL74573 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL71172 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL71220 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL70867 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL311625 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL72595 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL307318 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL302579 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL70789 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL70726 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL306638 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL302964 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL70935 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL73283 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL306761 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL71639 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL70370 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL308323 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL305017 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL69721 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL70100 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL70843 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL305238 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL307008 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL307359 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL74514 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL74069 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL303647 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL72099 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL309790 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL303427 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL312301 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL419073 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL70161 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL430792 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL70868 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL311253 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL70793 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL306340 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL307866 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL304065 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL311018 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL308482 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL306435 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL71286 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL74236 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL69839 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL309081 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL305239 | — | IC50 | = | 200.0 | nM | 6.70 |