Assay Detail
Binding
CHEMBL647575
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Inhibition of Angiotensin II receptor, type 1
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.42 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL346728 | — | — | 1 | 10.30 |
| CHEMBL338027 | — | — | 1 | 9.70 |
| CHEMBL63998 | — | — | 1 | 9.52 |
| CHEMBL294512 | — | — | 1 | 9.00 |
| CHEMBL288174 | — | — | 1 | 8.96 |
| CHEMBL290214 | — | — | 1 | 8.85 |
| CHEMBL39959 | — | — | 1 | 8.82 |
| CHEMBL263714 | — | — | 1 | 8.40 |
| CHEMBL308703 | — | — | 1 | 8.38 |
| CHEMBL348157 | — | — | 1 | 7.82 |
| CHEMBL74573 | — | — | 1 | 6.24 |
| CHEMBL267354 | — | — | 1 | 5.07 |
| CHEMBL292277 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL346728 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL338027 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL63998 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL294512 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL288174 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL290214 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL39959 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL263714 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL308703 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL348157 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL74573 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL267354 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL292277 | — | IC50 | > | 100000.0 | nM | - |