Assay Detail
Binding
CHEMBL647648
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration that causes 50% inhibition of mammalian cellobiase beta-glucosidase was determined in rat intestine
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Intestine |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Beta-glucosidase A (CHEMBL4622) ↗| Type | SINGLE PROTEIN |
| Organism | Caldicellulosiruptor saccharolyticus |
Publication
Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.24 | 4.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL312653 | — | — | 1 | 4.47 |
| CHEMBL456583 | — | — | 1 | 4.00 |
| CHEMBL307429 | DUVOGLUSTAT | 2.0 | 2 | - |
| CHEMBL2115197 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL312653 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL456583 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL307429 | DUVOGLUSTAT | IC50 | = | 460000.0 | nM | - |
| CHEMBL307429 | DUVOGLUSTAT | IC50 | = | 520000.0 | nM | - |
| CHEMBL2115197 | — | IC50 | = | 230000.0 | nM | - |