Assay Detail
Binding
CHEMBL647663
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for binding affinity against recombinant human Alpha-1A adrenergic receptor using [125I]HEAT in competition binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Determination of the relative and absolute stereochemistry of a potent and alpha1A-selective adrenoceptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.56 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96467 | — | — | 1 | 9.77 |
| CHEMBL2114249 | — | — | 1 | 9.05 |
| CHEMBL2111563 | — | — | 1 | 7.89 |
| CHEMBL2112365 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96467 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL2114249 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL2111563 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL2112365 | — | Ki | = | 30.0 | nM | 7.52 |