Assay Detail
Binding
CHEMBL647665
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Alpha-1A adrenergic receptor from human clone
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.99 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324090 | ABANOQUIL | 2.0 | 1 | 10.40 |
| CHEMBL25554 | — | — | 1 | 9.43 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.29 |
| CHEMBL707 | DOXAZOSIN | 4.0 | 1 | 8.59 |
| CHEMBL611 | TERAZOSIN | 4.0 | 1 | 8.14 |
| CHEMBL709 | ALFUZOSIN | 4.0 | 1 | 8.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324090 | ABANOQUIL | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL25554 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL2 | PRAZOSIN | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL707 | DOXAZOSIN | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL611 | TERAZOSIN | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL709 | ALFUZOSIN | Ki | = | 8.2 | nM | 8.09 |