Assay Detail
Binding
CHEMBL647725
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptor
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: discovery of a potential atypical antipsychotic agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.45 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 8.51 |
| CHEMBL346389 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15245 | YOHIMBINE | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL346389 | — | Ki | = | 411.0 | nM | 6.39 |