Assay Detail
Binding
CHEMBL647728
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Alpha-2A adrenergic receptor, from human clones.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.53 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25554 | — | — | 1 | 8.46 |
| CHEMBL114166 | — | — | 1 | 6.94 |
| CHEMBL707 | DOXAZOSIN | 4.0 | 1 | 6.14 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 5.67 |
| CHEMBL611 | TERAZOSIN | 4.0 | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25554 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL114166 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL707 | DOXAZOSIN | Ki | = | 729.0 | nM | 6.14 |
| CHEMBL2 | PRAZOSIN | Ki | = | 2133.0 | nM | 5.67 |
| CHEMBL611 | TERAZOSIN | Ki | = | 3702.0 | nM | 5.43 |