Assay Detail
Binding
CHEMBL647741
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Inhibitory constant against adenosine deaminase in 0.05 M sodium phosphate buffer at pH 7.0 was determined before heating
8
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Heat-induced formation of alpha,beta-unsaturated nucleoside dialdehydes and their activity with adenosine deaminase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 4.76 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280595 | — | — | 1 | 5.40 |
| CHEMBL2304163 | — | — | 2 | 4.55 |
| CHEMBL351404 | — | — | 1 | 4.34 |
| CHEMBL2304162 | — | — | 2 | - |
| CHEMBL168001 | — | — | 1 | - |
| CHEMBL353079 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280595 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL2304163 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL351404 | — | Ki | = | 46000.0 | nM | 4.34 |
| CHEMBL2304162 | — | Ki | = | 150000.0 | nM | - |
| CHEMBL2304162 | — | Ki | = | 430000.0 | nM | - |
| CHEMBL168001 | — | Ki | = | 370000.0 | nM | - |
| CHEMBL353079 | — | Ki | = | 780000.0 | nM | - |
| CHEMBL2304163 | — | Ki | = | 160000.0 | nM | - |