Assay Detail
Functional
CHEMBL647807
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Alpha-1 adrenergic receptor agonist activity in rabbit ear artery
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Artery |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Alpha-adrenergic agents. 1. Direct-acting alpha 1 agonists related to methoxamine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.68 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30596 | — | — | 1 | 6.92 |
| CHEMBL286702 | — | — | 1 | 6.77 |
| CHEMBL33405 | — | — | 1 | 6.70 |
| CHEMBL285082 | — | — | 1 | 6.47 |
| CHEMBL524 | METHOXAMINE | 4.0 | 1 | 6.14 |
| CHEMBL284486 | — | — | 1 | 5.28 |
| CHEMBL287047 | — | — | 1 | 4.96 |
| CHEMBL286609 | — | — | 1 | 4.52 |
| CHEMBL286226 | — | — | 1 | 4.52 |
| CHEMBL284307 | — | — | 1 | 4.52 |
| CHEMBL284257 | — | — | 1 | - |
| CHEMBL30294 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30596 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL286702 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL33405 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL285082 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL524 | METHOXAMINE | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL284486 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL287047 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL286609 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL286226 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL284307 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL284257 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL30294 | — | EC50 | > | 30000.0 | nM | - |