Assay Detail
Binding
CHEMBL647810
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Inhibition of specific [3H]prazosin binding (0.2 nM) to rat brain membranes alpha-1 adrenergic receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.98 | 7.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | 7.49 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.43 |
| CHEMBL31410 | CORYNANTHEINE | — | 1 | 6.60 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | Kd | = | 32.36 | nM | 7.49 |
| CHEMBL42 | CLOZAPINE | Kd | = | 37.15 | nM | 7.43 |
| CHEMBL31410 | CORYNANTHEINE | Kd | = | 251.19 | nM | 6.60 |
| CHEMBL15245 | YOHIMBINE | Kd | = | 398.11 | nM | 6.40 |