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Assay Detail

CHEMBL647839

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Alpha-2A adrenergic receptor (CHEMBL327)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.
Hieble JP, Bondinell WE, Ruffolo RR.
J Med Chem (1995) 38 : 3415 -3444
PubMed 7658428 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 7.42 8.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL597 PHENTOLAMINE 4.0 1 8.33
CHEMBL114166 1 6.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL597 PHENTOLAMINE Ki = 4.7 nM 8.33
CHEMBL114166 Ki = 313.0 nM 6.50