Assay Detail
Binding
CHEMBL647846
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The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Derivatives of 5-[[1-(4'-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.86 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339544 | — | — | 1 | 6.26 |
| CHEMBL125542 | — | — | 1 | 6.10 |
| CHEMBL338514 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339544 | — | IC50 | = | 549.0 | nM | 6.26 |
| CHEMBL125542 | — | IC50 | = | 789.0 | nM | 6.10 |
| CHEMBL338514 | — | IC50 | = | 5870.0 | nM | 5.23 |