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Assay Detail

CHEMBL647847

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Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Type-2 angiotensin II receptor (CHEMBL257)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Nonpeptide angiotensin II antagonists: N-phenyl-1H-pyrrole derivatives are angiotensin II receptor antagonists.
Bovy PR, Reitz DB, Collins JT, Chamberlain TS, Olins GM, Corpus VM, McMahon EG, Palomo MA, Koepke JP, Smits GJ.
J Med Chem (1993) 36 : 101 -110
PubMed 8421274 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.74 5.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL274447 1 5.48
CHEMBL276381 1 4.52
CHEMBL12190 1 4.23
CHEMBL191 LOSARTAN 4.0 1 -
CHEMBL12693 1 -
CHEMBL12810 1 -
CHEMBL267547 1 -
CHEMBL276150 1 -
CHEMBL13071 1 -
CHEMBL12451 1 -
CHEMBL12737 1 -
CHEMBL12548 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL274447 IC50 = 3300.0 nM 5.48
CHEMBL276381 IC50 = 30000.0 nM 4.52
CHEMBL12190 IC50 = 59000.0 nM 4.23
CHEMBL191 LOSARTAN IC50 > 10000.0 nM -
CHEMBL12693 IC50 = 230000.0 nM -
CHEMBL12810 IC50 = 260000.0 nM -
CHEMBL267547 IC50 = 140000.0 nM -
CHEMBL276150 IC50 = 810000.0 nM -
CHEMBL13071 IC50 = 220000.0 nM -
CHEMBL12451 IC50 = 450000.0 nM -
CHEMBL12737 IC50 = 159000.0 nM -
CHEMBL12548 IC50 = 930000.0 nM -