Assay Detail
Binding
CHEMBL647848
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The design, binding affinity prediction and synthesis of macrocyclic angiotensin II AT1 and AT2 receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.06 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302102 | — | — | 1 | 9.15 |
| CHEMBL168771 | — | — | 1 | 7.80 |
| CHEMBL176473 | — | — | 1 | 7.75 |
| CHEMBL174080 | — | — | 1 | 7.70 |
| CHEMBL368149 | — | — | 1 | 7.62 |
| CHEMBL408798 | — | — | 1 | 7.31 |
| CHEMBL408799 | — | — | 1 | 7.12 |
| CHEMBL367569 | — | — | 1 | 6.70 |
| CHEMBL367095 | — | — | 1 | 6.46 |
| CHEMBL173455 | — | — | 1 | 6.20 |
| CHEMBL173643 | — | — | 1 | 5.52 |
| CHEMBL172376 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302102 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL168771 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL176473 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL174080 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL368149 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL408798 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL408799 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL367569 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL367095 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL173455 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL173643 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL172376 | — | IC50 | = | 4000.0 | nM | 5.40 |