Assay Detail
Binding
CHEMBL647849
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Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A potent, orally active, balanced affinity angiotensin II AT1 antagonist and AT2 binding inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.28 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324629 | — | — | 1 | 9.40 |
| CHEMBL108981 | — | — | 1 | 9.22 |
| CHEMBL302102 | — | — | 1 | 9.15 |
| CHEMBL322471 | — | — | 1 | 9.10 |
| CHEMBL326217 | — | — | 1 | 6.68 |
| CHEMBL110265 | — | — | 1 | 5.66 |
| CHEMBL24861 | — | — | 1 | 5.66 |
| CHEMBL24322 | — | — | 1 | 5.35 |
| CHEMBL280526 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324629 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL108981 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL302102 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL322471 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL326217 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL110265 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL24861 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL24322 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL280526 | — | IC50 | = | 5350.0 | nM | 5.27 |