Assay Detail
Binding
CHEMBL647850
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Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
23
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Adrenal medulla |
| Subcellular | Microsome |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A novel series of selective, non-peptide inhibitors of angiotensin II binding to the AT2 site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.67 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128527 | — | — | 1 | 7.52 |
| CHEMBL336991 | — | — | 1 | 7.40 |
| CHEMBL340778 | — | — | 1 | 7.40 |
| CHEMBL128066 | — | — | 1 | 7.40 |
| CHEMBL292277 | — | — | 1 | 7.40 |
| CHEMBL340467 | — | — | 1 | 7.22 |
| CHEMBL340902 | — | — | 3 | 7.16 |
| CHEMBL339706 | — | — | 1 | 7.16 |
| CHEMBL339485 | — | — | 1 | 7.05 |
| CHEMBL338709 | — | — | 1 | 7.00 |
| CHEMBL131940 | — | — | 1 | 6.70 |
| CHEMBL128594 | — | — | 1 | 6.52 |
| CHEMBL128065 | — | — | 1 | 6.52 |
| CHEMBL340187 | — | — | 1 | 6.40 |
| CHEMBL340933 | — | — | 1 | 6.22 |
| CHEMBL419979 | — | — | 1 | 5.70 |
| CHEMBL419974 | — | — | 1 | 5.70 |
| CHEMBL128416 | — | — | 1 | 5.60 |
| CHEMBL127844 | — | — | 1 | 5.30 |
| CHEMBL340018 | — | — | 1 | 5.16 |
| CHEMBL128233 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128527 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL336991 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL340778 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL128066 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL292277 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL340467 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL340902 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL339706 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL340902 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL339485 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL340902 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL338709 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL131940 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL128594 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL128065 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL340187 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL340933 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL419974 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL419979 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL128416 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL127844 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL340018 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL128233 | — | IC50 | > | 10000.0 | nM | - |