Assay Detail
Binding
CHEMBL647851
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Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Midbrain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
L-162,389: a potent orally active angiotensin II receptor antagonist with balanced affinity to both AT1 and AT2 receptor subtypes
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.09 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39959 | — | — | 1 | 8.42 |
| CHEMBL449095 | — | — | 1 | 7.43 |
| CHEMBL105199 | — | — | 1 | 7.06 |
| CHEMBL318605 | — | — | 1 | 7.02 |
| CHEMBL293511 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39959 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL449095 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL105199 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL318605 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL293511 | — | IC50 | = | 2900.0 | nM | 5.54 |