Assay Detail
Binding
CHEMBL647853
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of a novel series of non-peptide AT2-selective angiotensin II receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.97 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL60071 | — | — | 1 | 9.40 |
| CHEMBL64861 | — | — | 1 | 9.22 |
| CHEMBL293660 | — | — | 1 | 9.15 |
| CHEMBL293625 | — | — | 1 | 8.96 |
| CHEMBL63109 | — | — | 1 | 8.85 |
| CHEMBL290829 | — | — | 1 | 8.82 |
| CHEMBL64881 | — | — | 1 | 8.77 |
| CHEMBL62422 | — | — | 1 | 8.57 |
| CHEMBL59913 | — | — | 1 | 8.35 |
| CHEMBL62744 | — | — | 1 | 8.15 |
| CHEMBL62754 | — | — | 1 | 8.11 |
| CHEMBL62806 | — | — | 1 | 8.00 |
| CHEMBL292939 | — | — | 1 | 7.92 |
| CHEMBL64280 | — | — | 1 | 7.82 |
| CHEMBL291818 | — | — | 1 | 7.82 |
| CHEMBL63046 | — | — | 1 | 7.82 |
| CHEMBL60209 | — | — | 1 | 7.70 |
| CHEMBL293195 | — | — | 1 | 7.64 |
| CHEMBL299887 | — | — | 1 | 7.52 |
| CHEMBL64575 | — | — | 1 | 7.46 |
| CHEMBL293414 | — | — | 1 | 7.43 |
| CHEMBL277567 | — | — | 1 | 7.40 |
| CHEMBL59854 | — | — | 1 | 7.16 |
| CHEMBL62157 | — | — | 1 | 7.09 |
| CHEMBL64714 | — | — | 1 | 6.77 |
| CHEMBL64674 | — | — | 1 | 6.75 |
| CHEMBL303755 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL60071 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL64861 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL293660 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL293625 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL63109 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL290829 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL64881 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL62422 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL59913 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL62744 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL62754 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL62806 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL292939 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL64280 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL291818 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL63046 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL60209 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL293195 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL299887 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL64575 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL293414 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL277567 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL59854 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL62157 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL64714 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL64674 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL303755 | — | IC50 | = | 230.0 | nM | 6.64 |