Assay Detail
ADMET
CHEMBL647916
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Inhibition of Aryl hydrocarbon hydroxylase in phenobarbitone-treated rats
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Inhibitors of hepatic mixed-function oxidases. 4. Effects of benzimidazole and related compounds on aryl hydrocarbon hydroxylase activity from phenobarbitone and 3-methylcholanthrene induced rats.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.38 | 4.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158007 | — | — | 1 | 4.75 |
| CHEMBL347036 | PROADIFEN HYDROCHLORIDE | -1.0 | 1 | 4.66 |
| CHEMBL345675 | — | — | 1 | 4.62 |
| CHEMBL14145 | — | — | 1 | 4.48 |
| CHEMBL155867 | — | — | 1 | 4.09 |
| CHEMBL156313 | — | — | 1 | 4.08 |
| CHEMBL351132 | DIMEDAZOL | — | 1 | 4.01 |
| CHEMBL306226 | BENZIMIDAZOLE | -1.0 | 1 | - |
| CHEMBL156439 | — | — | 1 | - |
| CHEMBL309135 | — | — | 1 | - |
| CHEMBL348508 | — | — | 1 | - |
| CHEMBL156134 | — | — | 1 | - |
| CHEMBL351569 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158007 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL347036 | PROADIFEN HYDROCHLORIDE | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL345675 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL14145 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL155867 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL156313 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL351132 | DIMEDAZOL | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL306226 | BENZIMIDAZOLE | IC50 | = | 1100000.0 | nM | - |
| CHEMBL156439 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL309135 | — | IC50 | = | 670000.0 | nM | - |
| CHEMBL348508 | — | IC50 | = | 480000.0 | nM | - |
| CHEMBL156134 | — | IC50 | = | 170000.0 | nM | - |
| CHEMBL351569 | — | IC50 | = | 630000.0 | nM | - |