Assay Detail
Binding
CHEMBL647947
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Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase M (AP-M) using [3H]Leu-enkephalin as substrate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Analgesic dipeptide derivatives. 7. 3,7-Diamino-2-hydroxyheptanoic acid (DAHHA) containing dipeptide analogues of the analgesic compound H-Lys-Trp(Nps)-OMe.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.60 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL354438 | — | — | 1 | 5.16 |
| CHEMBL171497 | — | — | 1 | 4.04 |
| CHEMBL170314 | — | — | 1 | - |
| CHEMBL169360 | — | — | 1 | - |
| CHEMBL1794905 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL354438 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL171497 | — | IC50 | = | 91200.0 | nM | 4.04 |
| CHEMBL170314 | — | IC50 | = | 225000.0 | nM | - |
| CHEMBL169360 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1794905 | — | IC50 | > | 1000000.0 | nM | - |