Assay Detail
Binding
CHEMBL647963
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Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Yohimbine dimers exhibiting binding selectivities for human alpha2a- versus alpha2b-adrenergic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.65 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL554019 | — | — | 1 | 9.41 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 9.38 |
| CHEMBL538808 | — | — | 1 | 9.12 |
| CHEMBL543232 | — | — | 1 | 9.06 |
| CHEMBL551711 | — | — | 1 | 8.93 |
| CHEMBL539606 | — | — | 1 | 8.90 |
| CHEMBL542527 | — | — | 1 | 8.87 |
| CHEMBL555190 | — | — | 1 | 8.76 |
| CHEMBL539824 | — | — | 1 | 7.82 |
| CHEMBL542520 | — | — | 1 | 7.58 |
| CHEMBL540594 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL554019 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL15245 | YOHIMBINE | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL538808 | — | Ki | = | 0.76 | nM | 9.12 |
| CHEMBL543232 | — | Ki | = | 0.87 | nM | 9.06 |
| CHEMBL551711 | — | Ki | = | 1.18 | nM | 8.93 |
| CHEMBL539606 | — | Ki | = | 1.25 | nM | 8.90 |
| CHEMBL542527 | — | Ki | = | 1.35 | nM | 8.87 |
| CHEMBL555190 | — | Ki | = | 1.73 | nM | 8.76 |
| CHEMBL539824 | — | Ki | = | 15.3 | nM | 7.82 |
| CHEMBL542520 | — | Ki | = | 26.4 | nM | 7.58 |
| CHEMBL540594 | — | Ki | = | 52.0 | nM | 7.28 |