Assay Detail
Binding
CHEMBL647970
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Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.99 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1788222 | — | — | 1 | 6.35 |
| CHEMBL302021 | — | — | 1 | 6.26 |
| CHEMBL1788223 | — | — | 1 | 6.06 |
| CHEMBL51433 | — | — | 1 | 5.74 |
| CHEMBL2092927 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1788222 | — | Ki | = | 444.0 | nM | 6.35 |
| CHEMBL302021 | — | Ki | = | 547.0 | nM | 6.26 |
| CHEMBL1788223 | — | Ki | = | 872.0 | nM | 6.06 |
| CHEMBL51433 | — | Ki | = | 1811.0 | nM | 5.74 |
| CHEMBL2092927 | — | Ki | = | 3000.0 | nM | 5.52 |