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Assay Detail

CHEMBL648051

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]clonidine from calf cerebral cortex alpha-2 adrenergic receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Tissue Cerebral cortex
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines.
Saari WS, Halczenko W, Huff JR, Guare JP, Hunt CA, Randall WC, Lotti VJ, Yarbrough GG.
J Med Chem (1984) 27 : 1182 -1185
PubMed 6088770 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 7.14 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL280514 1 8.30
CHEMBL6437 MIANSERIN 4.0 1 7.77
CHEMBL10347 RAUWOLSCINE 1 7.75
CHEMBL18194 1 7.66
CHEMBL18094 1 7.43
CHEMBL15245 YOHIMBINE 3.0 1 7.31
CHEMBL17605 1 7.24
CHEMBL17926 1 7.14
CHEMBL278934 1 6.84
CHEMBL17223 1 6.77
CHEMBL17648 1 6.38
CHEMBL18306 1 6.14
CHEMBL18270 1 6.12

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL280514 Ki = 5.0 nM 8.30
CHEMBL6437 MIANSERIN Ki = 17.0 nM 7.77
CHEMBL10347 RAUWOLSCINE Ki = 18.0 nM 7.75
CHEMBL18194 Ki = 22.0 nM 7.66
CHEMBL18094 Ki = 37.0 nM 7.43
CHEMBL15245 YOHIMBINE Ki = 49.0 nM 7.31
CHEMBL17605 Ki = 57.0 nM 7.24
CHEMBL17926 Ki = 72.0 nM 7.14
CHEMBL278934 Ki = 144.0 nM 6.84
CHEMBL17223 Ki = 170.0 nM 6.77
CHEMBL17648 Ki = 420.0 nM 6.38
CHEMBL18306 Ki = 720.0 nM 6.14
CHEMBL18270 Ki = 750.0 nM 6.12