Assay Detail
Binding
CHEMBL648169
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and structure-activity relationships of a new series of alpha-adrenergic agonists: spiro[(1,3-diazacyclopent-1-ene)-5,2'-(1',2',3',4'- tetrahydronaphthalene)].
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.62 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL133231 | — | — | 1 | 8.80 |
| CHEMBL338683 | — | — | 1 | 8.52 |
| CHEMBL98471 | — | — | 1 | 8.15 |
| CHEMBL336332 | — | — | 1 | 7.92 |
| CHEMBL131220 | — | — | 1 | 7.92 |
| CHEMBL130853 | — | — | 1 | 7.47 |
| CHEMBL133579 | — | — | 1 | 7.29 |
| CHEMBL131417 | — | — | 1 | 7.29 |
| CHEMBL336970 | — | — | 1 | 7.06 |
| CHEMBL101340 | — | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL133231 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL338683 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL98471 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL336332 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL131220 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL130853 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL133579 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL131417 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL336970 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL101340 | — | Ki | = | 1560.0 | nM | 5.81 |