Assay Detail
Functional
CHEMBL648226
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Growth inhibition on human burkitt lymphoma cells after 36 h
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Burkitts lymphoma cell |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.11 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL153593 | — | — | 1 | 7.70 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.30 |
| CHEMBL3085279 | — | — | 1 | 7.22 |
| CHEMBL346395 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL153593 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL107 | COLCHICINE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3085279 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL346395 | — | IC50 | = | 600.0 | nM | 6.22 |