Assay Detail
Functional
CHEMBL648233
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [14C]-cytidine incorporation into DNA in Burkitt''s lymphoma cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | lymphoma |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, cytotoxicity, and antitumor activity of copper(II) and iron(II) complexes of (4)N-azabicyclo[3.2.2]nonane thiosemicarbazones derived from acyl diazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.86 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71931 | N-[(1E)-1-(3-methylpyrazin-2-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex | — | 1 | 6.75 |
| CHEMBL307750 | N-[(1E)-1-(6-methylpyrimidin-4-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex | — | 1 | 6.68 |
| CHEMBL68899 | — | — | 1 | 6.50 |
| CHEMBL307351 | — | — | 1 | 5.68 |
| CHEMBL303030 | N-[(1E)-1-(5-methylpyrazin-2-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex | — | 1 | 5.53 |
| CHEMBL68043 | — | — | 1 | 5.48 |
| CHEMBL467 | HYDROXYUREA | 4.0 | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71931 | N-[(1E)-1-(3-methylpyrazin-2-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL307750 | N-[(1E)-1-(6-methylpyrimidin-4-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL68899 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL307351 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL303030 | N-[(1E)-1-(5-methylpyrazin-2-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL68043 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL467 | HYDROXYUREA | IC50 | = | 37150.0 | nM | 4.43 |