Assay Detail
Binding
CHEMBL648364
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In vitro inhibitory activity against the recombinant Mycobacterium tuberculosis Beta-ketoacyl-ACP synthase III mtFabH condensing enzyme.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Mycobacterial beta-ketoacyl-[acyl-carrier-protein] synthase III (CHEMBL3640) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.44 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124220 | — | — | 1 | 4.77 |
| CHEMBL122848 | — | — | 1 | 4.72 |
| CHEMBL123594 | — | — | 1 | 4.60 |
| CHEMBL123181 | — | — | 1 | 4.54 |
| CHEMBL333571 | — | — | 1 | 4.37 |
| CHEMBL333742 | — | — | 1 | 4.29 |
| CHEMBL332364 | — | — | 1 | 4.28 |
| CHEMBL123595 | — | — | 1 | 4.28 |
| CHEMBL331347 | — | — | 1 | 4.13 |
| CHEMBL122699 | — | — | 1 | - |
| CHEMBL123998 | — | — | 1 | - |
| CHEMBL123876 | — | — | 1 | - |
| CHEMBL331729 | — | — | 1 | - |
| CHEMBL333467 | — | — | 1 | - |
| CHEMBL124117 | — | — | 1 | - |
| CHEMBL432983 | — | — | 1 | - |
| CHEMBL332417 | — | — | 1 | - |
| CHEMBL123184 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124220 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL122848 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL123594 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL123181 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL333571 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL333742 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL332364 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL123595 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL331347 | — | IC50 | = | 74900.0 | nM | 4.13 |
| CHEMBL122699 | — | IC50 | = | 263000.0 | nM | - |
| CHEMBL123998 | — | IC50 | = | 153000.0 | nM | - |
| CHEMBL123876 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL331729 | — | IC50 | = | 246000.0 | nM | - |
| CHEMBL333467 | — | IC50 | = | 155000.0 | nM | - |
| CHEMBL124117 | — | IC50 | = | 119000.0 | nM | - |
| CHEMBL432983 | — | IC50 | = | 112000.0 | nM | - |
| CHEMBL332417 | — | IC50 | = | 215000.0 | nM | - |
| CHEMBL123184 | — | IC50 | > | 500000.0 | nM | - |