Assay Detail
Binding
CHEMBL648365
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Inhibitory activity against recombinant Mycobacterium tuberculosis beta-ketoacyl-Acyl Carrier Protein synthase mtFabH condensing enzyme
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Acetylene-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.62 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339331 | — | — | 1 | 5.40 |
| CHEMBL124012 | — | — | 1 | 5.16 |
| CHEMBL333744 | — | — | 1 | 5.16 |
| CHEMBL124220 | — | — | 1 | 4.77 |
| CHEMBL126054 | — | — | 1 | 4.47 |
| CHEMBL124086 | — | — | 1 | 4.32 |
| CHEMBL399043 | THIOLACTOMYCIN | — | 1 | 4.13 |
| CHEMBL123723 | — | — | 1 | 4.13 |
| CHEMBL122046 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339331 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL124012 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL333744 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL124220 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL126054 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL124086 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL399043 | THIOLACTOMYCIN | IC50 | = | 74900.0 | nM | 4.13 |
| CHEMBL123723 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL122046 | — | IC50 | = | 100000.0 | nM | 4.00 |