Assay Detail
Functional
CHEMBL648369
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Compound was tested for inhibition of Bacillus licheniformis 749/C, class A of beta-Lactamases.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bacillus licheniformis |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.60 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6461 | Ro-481220 | — | 1 | 6.50 |
| CHEMBL333078 | — | — | 1 | 6.50 |
| CHEMBL123702 | — | — | 1 | 5.77 |
| CHEMBL124961 | — | — | 1 | 5.47 |
| CHEMBL124227 | — | — | 1 | 5.44 |
| CHEMBL124960 | — | — | 1 | 5.41 |
| CHEMBL124507 | — | — | 1 | 5.36 |
| CHEMBL2111804 | — | — | 1 | 5.22 |
| CHEMBL123029 | — | — | 1 | 5.19 |
| CHEMBL333581 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6461 | Ro-481220 | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL333078 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL123702 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL124961 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL124227 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL124960 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL124507 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL2111804 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL123029 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL333581 | — | IC50 | = | 6600.0 | nM | 5.18 |