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Assay Detail

CHEMBL648492

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity for Angiotensin II receptor, type 1
ChEMBL ↗
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Type-1 angiotensin II receptor (CHEMBL227) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Balanced angiotensin II receptor antagonists. III. The effects of substitution at the imidazole 5-position.
Santella JB, Duncia JV, Ensinger CL, VanAtten MK, Carini DJ, Wexler RR, Chiu AT, Wong PC, Timmermans PB
Bioorg Med Chem Lett (1994) 4 : 2235 -2240
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 61 9.18 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL70370 — — 1 10.00
CHEMBL305017 — — 1 10.00
CHEMBL69721 — — 1 10.00
CHEMBL307318 — — 1 10.00
CHEMBL70789 — — 1 10.00
CHEMBL70843 — — 1 10.00
CHEMBL305238 — — 1 10.00
CHEMBL70935 — — 1 10.00
CHEMBL70161 — — 1 10.00
CHEMBL311253 — — 1 9.70
CHEMBL71172 — — 1 9.70
CHEMBL71639 — — 1 9.70
CHEMBL73283 — — 1 9.70
CHEMBL308323 — — 1 9.70
CHEMBL311625 — — 1 9.70
CHEMBL430792 — — 1 9.70
CHEMBL303427 — — 1 9.70
CHEMBL70868 — — 1 9.70
CHEMBL302964 — — 1 9.70
CHEMBL70726 — — 1 9.55
CHEMBL71286 — — 1 9.52
CHEMBL303647 — — 1 9.52
CHEMBL70867 — — 1 9.52
CHEMBL302579 — — 1 9.52
CHEMBL309790 — — 1 9.52
CHEMBL306340 — — 1 9.52
CHEMBL311018 — — 1 9.52
CHEMBL306638 — — 1 9.46
CHEMBL307359 — — 1 9.40
CHEMBL312301 — — 1 9.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL70370 — IC50 = 0.1 nM 10.00
CHEMBL305017 — IC50 = 0.1 nM 10.00
CHEMBL69721 — IC50 = 0.1 nM 10.00
CHEMBL307318 — IC50 = 0.1 nM 10.00
CHEMBL70789 — IC50 = 0.1 nM 10.00
CHEMBL70843 — IC50 = 0.1 nM 10.00
CHEMBL305238 — IC50 = 0.1 nM 10.00
CHEMBL70935 — IC50 = 0.1 nM 10.00
CHEMBL70161 — IC50 = 0.1 nM 10.00
CHEMBL303427 — IC50 = 0.2 nM 9.70
CHEMBL71172 — IC50 = 0.2 nM 9.70
CHEMBL71639 — IC50 = 0.2 nM 9.70
CHEMBL73283 — IC50 = 0.2 nM 9.70
CHEMBL311253 — IC50 = 0.2 nM 9.70
CHEMBL308323 — IC50 = 0.2 nM 9.70
CHEMBL311625 — IC50 = 0.2 nM 9.70
CHEMBL430792 — IC50 = 0.2 nM 9.70
CHEMBL70868 — IC50 = 0.2 nM 9.70
CHEMBL302964 — IC50 = 0.2 nM 9.70
CHEMBL70726 — IC50 = 0.28 nM 9.55
CHEMBL306340 — IC50 = 0.3 nM 9.52
CHEMBL311018 — IC50 = 0.3 nM 9.52
CHEMBL309790 — IC50 = 0.3 nM 9.52
CHEMBL70867 — IC50 = 0.3 nM 9.52
CHEMBL303647 — IC50 = 0.3 nM 9.52
CHEMBL71286 — IC50 = 0.3 nM 9.52
CHEMBL302579 — IC50 = 0.3 nM 9.52
CHEMBL306638 — IC50 = 0.35 nM 9.46
CHEMBL307359 — IC50 = 0.4 nM 9.40
CHEMBL312301 — IC50 = 0.4 nM 9.40
CHEMBL69839 — IC50 = 0.4 nM 9.40
CHEMBL74573 — IC50 = 0.5 nM 9.30
CHEMBL307008 — IC50 = 0.5 nM 9.30
CHEMBL72595 — IC50 = 0.5 nM 9.30
CHEMBL71125 — IC50 = 0.57 nM 9.24
CHEMBL71220 — IC50 = 0.6 nM 9.22
CHEMBL72099 — IC50 = 0.6 nM 9.22
CHEMBL304065 — IC50 = 0.6 nM 9.22
CHEMBL74236 — IC50 = 0.6 nM 9.22
CHEMBL419073 — IC50 = 0.6 nM 9.22
CHEMBL70100 — IC50 = 0.74 nM 9.13
CHEMBL74514 — IC50 = 0.8 nM 9.10
CHEMBL74069 — IC50 = 0.8 nM 9.10
CHEMBL306435 — IC50 = 0.8 nM 9.10
CHEMBL306761 — IC50 = 1.0 nM 9.00
CHEMBL308482 — IC50 = 1.0 nM 9.00
CHEMBL70353 — IC50 = 2.0 nM 8.70
CHEMBL306924 — IC50 = 3.0 nM 8.52
CHEMBL307866 — IC50 = 3.0 nM 8.52
CHEMBL70793 — IC50 = 3.0 nM 8.52