Assay Detail
Binding
CHEMBL648536
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Inhibitory activity towards Beta-Glucosidase from Caldocellum saccharol
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Caldicellulosiruptor saccharolyticus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Beta-glucosidase A (CHEMBL4622) ↗| Type | SINGLE PROTEIN |
| Organism | Caldicellulosiruptor saccharolyticus |
Publication
Derivatives of (2R,3R,4S)-2-aminomethylpyrrolidine-3,4-diol are selective alpha-mannosidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 4.56 | 4.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2115197 | — | — | 1 | 4.72 |
| CHEMBL2207397 | — | — | 1 | 4.72 |
| CHEMBL83278 | — | — | 1 | 4.57 |
| CHEMBL313295 | — | — | 1 | 4.22 |
| CHEMBL82895 | — | — | 1 | - |
| CHEMBL2206827 | — | — | 1 | - |
| CHEMBL84272 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2115197 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL2207397 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL83278 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL313295 | — | Ki | = | 60000.0 | nM | 4.22 |
| CHEMBL82895 | — | Ki | = | 120000.0 | nM | - |
| CHEMBL2206827 | — | Ki | = | 170000.0 | nM | - |
| CHEMBL84272 | — | Ki | = | 120000.0 | nM | - |